Mr. Rough ER | Criminal Organelle

Rough Endoplasmic Reticulum Criminal Records Found!

Mr. Rough ER

Mr. Rough ER lives up to his name. Rough around the edges, he not only has a criminal history but also takes up 50% of the cell, leaving little room for others. 

Mr. Rough ER is an unforgiving organelle. His role in many diseases have plagued his record with foul play.  

After researching his background, we came across his criminal records. Let's take a look.

1st Offense: Domestic violence by ER stress. Mr. Rough ER caused an accumulation of unfolded or misfolded protetins.

Status: Probation for 1 year.

2nd Offense: First degree murder by Parkinson's Disease and Alzheimer's Disease.

Status: 12 years in prison.

3rd Offense: Assault. Mr. Rough ER activated JNK who assisted him in insulin resistance through phosphorylating insulin receptor substrate. 
Status: 5 years in prison.

Parkinson's Disease

Type II Diabetes

While under stress, Mr Rough ER's functions are impaired causing alteration to protein homeostasis. If Mr. Rough ER served as Organelle in Chief, he would crack under pressure, and it would be humiliating for Eukarya to have a criminal in office.

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